Fig. 1.

Aggravation of EAE by oligodendroglia-specific Cx47 ablation. (A) Clinical scores in Cx47 fl/fl control (blue; n = 8) and Cx47 icKO (red; n = 9) mice. (B and C) Severity of disease symptoms evaluated by comparing the AUC values (B) from dpi 0 to dpi 29 (acute phase, 8 Cx47 fl/fl mice vs. 9 Cx47 icKO mice) and (C) from dpi 30 to dpi 72 (chronic phase, 5 Cx47 fl/fl mice vs. 6 Cx47 icKO mice). (D) Comparisons of clinical features of EAE between Cx47 icKO and Cx47 fl/fl mice. The sums of three independent experiments are shown. All data are shown as means ± SEM. P values were calculated by the Mann–Whitney U test. ***P < 0.001.