Table 3.
Baseline Person-Based Characteristics Associated with Accelerated Knee Osteoarthritis (AKOA) During Each Phase
| Phase 1: Year 1 - Year 5 (n = 715; 702 in model) | |||||||
| Variable | No KOA (n = 585) | Typical KOA (n = 92) | AKOA (n = 25) | AKOA vs No KOA | AKOA vs Typical KOA | AKOA vs No KOA | AKOA vs Typical KOA |
| m (sd) | m (sd) | m (sd) | OR (95% CI) | OR (95% CI) | aOR (95% CI) | aOR (95% CI) | |
| Age (sd = 5.8 years) | 53.7 (5.9) | 55.6 (5.3) | 56.7 (5.0) | 1.65 (1.10, 2.47) | 1.20 (0.77, 1.87) | 1.88 (1.21, 2.93) | 1.29 (0.79, 2.10) |
| BMI (sd = 3.9 kg/m2) | 24.9 (3.7) | 26.4 (4.6) | 25.9 (3.8) | 1.30 (0.90, 1.87) | 0.91 (0.61, 1.34) | 1.30 (0.87, 1.93) | 0.87 (0.57, 1.34) |
| Systolic BP (sd = 20 mmHg) | 127 (21) | 128 (19) | 126 (15) | 0.95 (0.63, 1.44) | 0.90 (0.58, 1.42) | 0.44 (0.21, 0.91) | 0.53 (0.24, 1.16) |
| Diastolic BP (sd = 11 mmHg) | 78 (11) | 79 (11) | 80 (8) | 1.22 (0.84, 1.77) | 1.13 (0.74, 1.71) | 1.75 (0.91, 3.36) | 1.78 (0.87, 3.62) |
| Phase 2: Year 5 - Year 10 (n = 574; 539 used in model) | |||||||
| Variable | No KOA (n = 365) | Typical KOA (n = 157) | AKOA (n = 17) | AKOA vs No KOA | AKOA vs Typical KOA | AKOA vs No KOA | AKOA vs Typical KOA |
| m (sd) | m (sd) | m (sd) | OR (95% CI) | OR (95% CI) | aOR (95% CI) | aOR (95% CI) | |
| Age (sd = 5.8 years) | 57.2 (5.6) | 58.1 (5.8) | 62.1 (6.5) | 2.33 (1.39, 3.90) | 1.98 (1.17, 3.35) | 2.87 (1.61, 5.11) | 2.54 (1.41, 4.56) |
| BMI (sd = 4.1 kg/m2) | 25.5 (3.8) | 26.4 (4.6) | 29.1 (4.6) | 1.96 (1.35, 2.86) | 1.55 (1.06, 2.26) | 2.76 (1.69, 4.52) | 2.26 (1.37, 3.71) |
| Systolic BP (sd = 19 mmHg) | 123 (19) | 127 (20) | 125 (16) | 1.09 (0.67, 1.77) | 0.89 (0.54, 1.46) | 0.89 (0.47, 1.68) | 0.81 (0.42, 1.54) |
| Diastolic BP (sd = 12 mmHg) | 74 (12) | 75.6 (13) | 69.4 (15) | 0.66 (0.38, 1.14) | 0.56 (0.32, 0.99) | 0.39 (0.20, 0.75) | 0.38 (0.20, 0.74) |
| Phase 3: Year 10 - Year 15 (n = 377; 374 used in model) | |||||||
| Variable | No KOA (n = 272) | Typical KOA (n = 82) | AKOA (n = 20) | AKOA vs No KOA | AKOA vs Typical KOA | AKOA vs No KOA | AKOA vs Typical KOA |
| m (sd) | m (sd) | m (sd) | OR (95% CI) | OR (95% CI) | aOR (95% CI) | aOR (95% CI) | |
| Age (sd = 5.5 years) | 61.4 (5.5) | 61.1 (5.1) | 63.9 (6.4) | 1.52 (0.98, 2.35) | 1.62 (1.01, 2.60) | 1.38 (0.88, 2.15) | 1.35 (0.83, 2.22) |
| BMI (sd = 3.9 kg/m2) | 25.5 (3.7) | 26.7 (4.4) | 26.1 (3.8) | 1.17 (0.75, 1.83) | 0.87 (0.54, 1.40) | 1.08 (0.67, 1.74) | 0.78 (0.47, 1.31) |
| Systolic BP (sd = 21 mmHg) | 135 (23) | 131 (15) | 146 (24) | 1.47 (1.02, 2.12) | 1.87 (1.22, 2.89) | 1.32 (0.78, 2.27) | 2.13 (1.14, 4.01) |
| Diastolic BP (sd = 11 mmHg) | 80 (11) | 81 (10) | 84 (13) | 1.36 (0.89, 2.10) | 1.33 (0.83, 2.11) | 1.05 (0.57, 1.91) | 0.82 (0.43, 1.58) |
| Meta-Analysis of Baseline Characteristics from the 3 Phases | |||||||
| Variable | AKOA vs No KOA | AKOA vs Typical KOA | AKOA vs No KOA | AKOA vs Typical KOA | |||
| OR (95% CI) | OR (95% CI) | aOR (95% CI) | aOR (95% CI) | ||||
| Age (sd = 5.8 years) | 1.75 (1.35 to 2.26) | 1.52 (1.16 to 2.01) | 1.84 (1.40 to 2.43) | 1.56 (1.16 to 2.11) | |||
| BMI (sd = 3.9 kg/m2) | 1.47 (1.17 to 1.84) | 1.11 (0.87 to 1.40) | 1.52 (1.17 to 1.97) | 1.13 (0.86 to 1.48) | |||
| Systolic BP (sd = 20 mmHg) | 1.18 (0.93 to 1.50) | 1.18 (0.91 to 1.53) | 0.90 (0.63 to 1.28) | 1.06 (0.72 to 1.57) | |||
| Diastolic BP (sd = 11 mmHg) | 1.11 (0.87 to 1.43) | 1.01 (0.77 to 1.33) | 0.91 (0.63 to 1.31) | 0.79 (0.53 to 1.16) | |||
KOA knee osteoarthritis, m mean, sd standard deviation, OR odds ratio (per 1 standard deviation), 95% CI 95% confidence interval, aOR adjusted odds ratio (adjusted for other variables in table), BMI body mass index, BP blood pressure
All boldface entries are statistically significant (p < 0.05) with confidence intervals that don't include 1.00