Table 2.
Infectious titre production of ABBV-1 in immortalized cell lines
| Experiment 1 | Homologous Titration (Log FFU / 106 cells) | Heterologous Titration (Log FFU / 106 cells) | ||||||
|---|---|---|---|---|---|---|---|---|
| Passage | CCL-141 ABBV-1 | QT-35 ABBV-1 | DF-1 ABBV-1 | P value | CCL-141 ABBV-1 | QT-35 ABBV-1 | DF-1 ABBV-1 | P value |
| 8 | 5.11 | 2.68 | NT | 4.86 | 2.02 | NT | ||
| 12 | 3.98 | 2.43 | NT | 4.48 | 1.93 | NT | ||
| 13 | 3.92 | 3.18 | NT | 4.67 | 3.09 | NT | ||
| Mean ± SD | 4.34 ± 0.67 | 2.76 ± 0.38 | N/A | * | 4.67 ± 0.19 | 2.35 ± 0.65 | N/A | ** |
| Experiment 2 | Homologous Titration (Log FFU / 106 cells) | Heterologous Titration (Log FFU / 106 cells) | ||||||
| Passage | CCL-141 ABBV-1 | QT-35 ABBV-1 | DF-1 ABBV-1 | P value | CCL-141 ABBV-1 | QT-35 ABBV-1 | DF-1 ABBV-1 | P value |
| 6 | 4.57 | 1.82 | NT | 4.49 | NT | NT | ||
| 7 | 4.40 | NT | NT | 4.49 | NT | NT | ||
| 8 | 4.49 | 1.82 | NT | 4.66 | NT | NT | ||
| 10 | 3.32 | 2.90 | NT | 3.11 | 2.49 | NT | ||
| 11 | 3.61 | 2.66 | NT | 3.36 | 2.40 | NT | ||
| 12 | 2.94 | 2.74 | NT | 3.11 | 2.66 | 2.06 | ||
| Mean ± SD | 3.89 ± 0.69 | 2.39 ± 0.52 | N/A | ** | 3.87 ± 0.75 | 2.52 ± 0.13 | N/A | * |
NT – no measurable titre and not included in statistical analysis
N/A – not applicable
The mean is the average of all measurable titre within each experiment for each cell line. The SD is the standard deviation of all measurable titre within each experiment for each cell line. Mean ± SD was not calculated for DF-1 ABBV-1 because there was either no measurable titre or only one measurable titre
* P < 0.05, ** P < 0.01. P value indicates statistical significance between CCL-141 ABBV-1 and QT-35 ABBV-1. Statistical analysis was not performed on DF-1 ABBV-1 due to lack of measurable titre for all but one passage