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. 2020 Jan 31;20:27. doi: 10.1186/s12890-020-1060-y

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Relative change in (a) SP-A, (b) SP-D, and (c) KL-6 levels in the initial 3 and 6 months. Changes in serum SP-A at 3 and 6 months, SP-D at 6 months, and KL-6 at 3 and 6 months were significantly smaller in the stable group than the progression group (*p < 0.05). Data were analyzed by Mann–Whitney U test. Horizontal line indicates median concentration. The upper and lower limits of the box indicate the inter quartile range