Table 4.
Gen category and function | Gen symbol | Fold changea | P-valueb |
---|---|---|---|
Lipid uptake and transport | |||
Fatty acid transporter | cd36 | 1.13 | 0.175 |
Fatty acid transporter | fabp2b | 1.37 | 0.004 |
Fatty acid transporter | fabp2a1 | 1.11 | 0.302 |
Fatty acid transporter | fabp2a2 | 1.01 | 0.962 |
Fatty acid transporter | fatp | 0.89 | 0.120 |
Lipoprotein assembly | mtp | 1.12 | 0.259 |
Lipoprotein component | apoB48 | 1.07 | 0.730 |
Lipoprotein component | apoAIV | 1.58 | 0.028 |
Lipoprotein component | apoAI | 1.42 | 0.001 |
Lipid droplet component | plin2 | 0.273 | < 0.001 |
Nuclear receptor – regular of lipid metabolism | pparα | 1.52 | 0.037 |
Nuclear receptor – regular of lipid metabolism | pparγ | 1.38 | 0.024 |
Resynthesis of triacylglycerols | mgat2a | 1.39 | 0.023 |
Phosphatidylcholine synthesis | |||
Choline transporter | slc44a2 | 1.09 | 0.329 |
Phosphatidylcholine biosynthesis | pemt | 0.95 | 0.486 |
Phosphatidylcholine biosynthesis | chk | 0.61 | 0.068 |
Phosphatidylcholine biosynthesis | pcyt1a | 0.58 | 0.004 |
Cholesterol metabolism | |||
Bile acid nuclear receptor | fxr | 1.15 | 0.415 |
Cholesterol biosynthesis | hmgcr | 0.91 | 0.260 |
Cholesterol efflux transporter | abca1 | 0.95 | 0.650 |
Cholesterol efflux transporter | abcg5 | 1.61 | 0.004 |
Cholesterol esterification | acat | 0.95 | 0.677 |
Cholesterol transporter | npc1l1 | 1.58 | < 0.001 |
Nuclear receptor - regular of lipid and sterol metabolism | lxr | 1.06 | 0.580 |
Nuclear receptor - regular of lipid and sterol metabolism | srebp1 | 0.55 | 0.159 |
Nuclear receptor - regular of lipid and sterol metabolism | srebp2 | 1.04 | 0.907 |
Taurine transporter - bile salt metabolism | slc6a6 | 1.39 | 0.001 |
aValues are mean fold change observed in the choline diet fed group in comparison with those in the control group
bP-values in bold indicate significant differences between the two treatments; italicized values represent trends