Table 5.
Gen category and function | Gen symbol | Fold changea | P-valueb |
---|---|---|---|
Lipid uptake and transport | |||
Fatty acid transporter | cd36 | 0.948 | 0.711 |
Fatty acid transporter | fatp | 0.992 | 0.923 |
Lipoprotein component | apo(B100)liver | 0.996 | 0.983 |
Lipid droplet component | plin2 | 1.626 | 0.013 |
Nuclear receptor – regular of lipid metabolism | pparα | 0.660 | 0.182 |
Nuclear receptor – regular of lipid metabolism | pparγ | 0.973 | 0.834 |
Phosphatidylcholine synthesis | |||
Phosphatidylcholine biosynthesis | pemt | 0.998 | 0.988 |
Phosphatidylcholine biosynthesis | chk | 0.505 | 0.116 |
Phosphatidylcholine biosynthesis | pcyt1a | 0.923 | 0.597 |
Cholesterol metabolism | abc1a1 | 0.851 | 0.310 |
Bile acid nuclear receptor | fxr | 1.154 | 0.265 |
Cholesterol biosynthesis | hmgcr | 0.936 | 0.479 |
Cholesterol biosynthesis | cyp7a1 | 0.925 | 0.580 |
Cholesterol efflux transporter | abca1 | 0.855 | 0.289 |
Cholesterol efflux transporter | |||
Cholesterol efflux transporter | abcg5 | 1.063 | 0.601 |
Cholesterol transporter | npc1l1 | 0.955 | 0.776 |
Nuclear receptor - regular of lipid and sterol metabolism | lxr | 0.837 | 0.156 |
Nuclear receptor - regular of lipid and sterol metabolism | srebp1 | 0.944 | 0.851 |
Nuclear receptor - regular of lipid and sterol metabolism | srebp2 | 1.174 | 0.405 |
ROS metabolism / antioxidant | |||
Superoxide dismutation | sod3 | 0.739 | 0.374 |
Nuclear receptor – control of gene transcription | |||
Transcription factor | rxr | 0.789 | 0.104 |
Mannose metabolism | |||
Glycosylation | pmm | 0.759 | 0.029 |
aValues are mean fold change observed in the choline diet fed group in comparison with those in the control group
bP-values in bold indicate significant differences between the two treatments; italicized values represent trends