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. 2020 Jan 31;21:38. doi: 10.1186/s12859-019-3334-z

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — The procedure of telomeric DNA bisulfite conversion and paired-end sequencing. The treatments and their productions are labeled as orange and green. The methylated and unmethylated cytosines in sequences are colored as red and blue respectively. The labels “centromere” and “telomere” indicate the direction of sequences or reads in genome. The numbers above C indicate the indexes of three non-CpG cytosines in telomeric DNA blocks.