Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 31;21:109. doi: 10.1186/s12864-020-6525-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 4 — A gene interaction network (Panel a) of lipogenic (green symbols) and lipolytic (red symbols) AR-DEGS found in the D1FED24h vs. D1FAST24h contrast. This gene network was functionally annotated by IPA as “Lipid Metabolism/Molecular Transport”. These genes are differentially regulated by two transcription factors [catenin beta 1 (CTNNB1) and activating transcription factor 4 (ATF4)]. Ingenuity® Upstream Regulator Analysis identified additional direct targets for each transcription factor (Panel b) and predicts that CTNNB1 should be inhibited due to down-regulation of its eight direct target genes (EGFR, EPCAM, EPHB2, IGFBP2, IRF8, LY6E, SESN1 and CYB5A), although the expression of CTNNB1 and seven direct target genes were up-regulated (i.e., higher in D1FED24h). Ingenuity correctly predicted activation of ATF4 and up-regulation of four direct target genes including CTNNB1 and another transcription factor, Jun proto-oncogene, AP-1 transcription factor subunit (JUN)