Table 4.
Odds ratios from multinomial logistic regression models for CKD stage 3 and stages 4–5 per μm increase in thickness of retinal layers supplied by the retinal microvasculature
| ETDRS segment | Right eye | Left eye | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CKD stage 3 (vs. stage 1–2) | CKD stage 4–5 (vs. stage 1–2) | CKD stage 3 (vs. stage 1–2) | CKD stage 4–5 (vs. stage 1–2) | |||||||||
| OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | OR | 95% CI | p | |
| Nerve fibre layer | ||||||||||||
| N1 | 0.99 | (0.86, 1.14) | 0.88 | 0.88 | (0.74, 1.05) | 0.15 | 1.01 | (0.90, 1.13) | 0.93 | 1.00 | (0.90, 1.11) | 0.95 |
| S1 | 1.05 | (0.96, 1.16) | 0.27 | 1.00 | (0.90, 1.11) | 0.97 | 1.03 | (0.94, 1.13) | 0.52 | 0.99 | (0.89, 1.10) | 0.85 |
| T1 | 0.83 | (0.64, 1.06) | 0.14 | 1.04 | (0.96, 1.13) | 0.35 | 0.95 | (0.77, 1.17) | 0.63 | 1.14 | (0.96, 1.36) | 0.14 |
| I1 | 0.97 | (0.87, 1.08) | 0.58 | 0.94 | (0.84, 1.06) | 0.31 | 1.02 | (0.92, 1.13) | 0.70 | 1.00 | (0.90, 1.11) | 0.94 |
| Ganglion cell layer | ||||||||||||
| N1 | 1.02 | (0.96, 1.09) | 0.48 | 0.93 | (0.87, 1.00) | 0.04* | 1.00 | (0.94, 1.07) | 0.98 | 0.94 | (0.87, 1.01) | 0.08 |
| S1 | 1.02 | (0.95, 1.09) | 0.60 | 0.92 | (0.86, 0.99) | 0.02* | 1.01 | (0.94, 1.09) | 0.75 | 0.95 | (0.88, 1.03) | 0.18 |
| T1 | 1.01 | (0.94, 1.08) | 0.87 | 0.89 | (0.82, 0.97) | 0.01* | 1.01 | (0.95, 1.07) | 0.74 | 0.93 | (0.87, 0.99) | 0.02* |
| I1 | 1.02 | (0.95, 1.10) | 0.57 | 0.90 | (0.83, 0.96) | 0.004* | 1.03 | (0.96, 1.10) | 0.47 | 0.90 | (0.84, 0.97) | 0.004* |
| Inner plexiform layer | ||||||||||||
| N1 | 1.01 | (0.92, 1.11) | 0.83 | 0.91 | (0.82, 1.00) | 0.04* | 0.99 | (0.91, 1.09) | 0.90 | 0.90 | (0.82, 1.00) | 0.04* |
| S1 | 1.01 | (0.92, 1.12) | 0.78 | 0.89 | (0.80, 0.99) | 0.03* | 0.99 | (0.89, 1.10) | 0.81 | 0.88 | (0.78, 0.99) | 0.03* |
| T1 | 1.00 | (0.90, 1.11) | 0.96 | 0.87 | (0.78, 0.98) | 0.02* | 1.03 | (0.93, 1.13) | 0.61 | 0.89 | (0.80, 0.99) | 0.03* |
| I1 | 1.01 | (0.90, 1.12) | 0.92 | 0.85 | (0.76, 0.96) | 0.01* | 1.02 | (0.92, 1.14) | 0.66 | 0.82 | (0.73, 0.93) | 0.002* |
| Inner nuclear layer | ||||||||||||
| N1 | 0.91 | (0.82, 1.02) | 0.10 | 0.9 | (0.79, 1.02) | 0.11 | 0.90 | (0.81, 1.01) | 0.07 | 0.96 | (0.86, 1.06) | 0.42 |
| S1 | 0.92 | (0.83, 1.02) | 0.11 | 0.9 | (0.80, 1.01) | 0.08 | 0.92 | (0.84, 1.01) | 0.09 | 0.88 | (0.79, 0.97) | 0.01* |
| T1 | 0.91 | (0.80, 1.03) | 0.14 | 0.87 | (0.75, 1.00) | 0.06 | 0.93 | (0.83, 1.03) | 0.17 | 0.88 | (0.78, 0.99) | 0.03* |
| I1 | 0.96 | (0.86, 1.06) | 0.42 | 0.96 | (0.84, 1.08) | 0.49 | 0.93 | (0.84, 1.03) | 0.16 | 0.89 | (0.79, 1.00) | 0.06 |
ETDRS Early Treatment Diabetic Retinopathy Study, OR Odds ratio, SD Standard deviation, CI Confidence interval, F Fovea, S1 Superior segment 1, N1 Nasal segment 1, I1 Inferior segment 1, T1 Temporal segment 1.*significant values. Adjustment for age, mean arterial blood pressure, diabetes status, low-density lipoprotein, body mass index, and sex