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Data from three sources were used to identify candidate susceptibility genes for CRC. RNA-seq data from normal colons was generated from cancer susceptible STS/A and cancer resistant Balb/cHeA mice. aCGH data from human CRCs was used to confirm that SCC loci for study were showing copy number changes. Allele-specific imbalance (ASI) studies were completed on paired normal and colon tumor DNAs for the orthologous human loci to Scc4, Scc5 and Scc13.
