Table 1.
Patients’ Characteristics
| Parameter | N | % |
|---|---|---|
| Gender | ||
| Male | 14 | 47 |
| Female | 16 | 53 |
| Age, years | ||
| Median | 59 | |
| Mean | 56 | |
| Range | 28-76 | |
| WHO grade initially | ||
| 3 | 7 | 23 |
| 4 | 23 | 77 |
| Time interval between initial RT and ReRT, months | ||
| Median | 10 | |
| Range | 3-154 | |
| Temozolomide during initial RT | ||
| Yes | 26 | 87 |
| No | 4 | 13 |
| IDH mutation initially | ||
| Yes | 3 | 10 |
| No | 25 | 83 |
| n.a. | 2 | 7 |
| TP53 mutation initially | ||
| Yes | 13 | 43 |
| No | 8 | 27 |
| n.a. | 9 | 30 |
| EGFR mutation initially | ||
| Yes | 12 | 40 |
| No | 12 | 40 |
| n.a. | 6 | 20 |
| Ki67 initially | ||
| <10 | 5 | 17 |
| 10-20 | 14 | 47 |
| >20 | 5 | 17 |
| n.a. | 6 | 20 |
| MGMT mutation initially | ||
| Yes | 17 | 57 |
| No | 12 | 40 |
| n.a. | 1 | 3 |
| ATRX loss initially | ||
| Yes | 20 | 67 |
| No | 4 | 13 |
| n.a. | 6 | 20 |
| Repeated surgery prior to ReRT | ||
| Biopsy | 4 | 13 |
| Partial resection | 7 | 23 |
| Gross total resection | 6 | 20 |
| No | 13 | 43 |
| Chemotherapy after ReRT | ||
| Yes | 24 | 80 |
| No | 6 | 20 |
| Volume CTV ReRT, ccm | ||
| Median | 52.25 | |
| Range | 6.5-224 | |
| Karnofsky Performance Score at ReRT | ||
| 100% | 0 | 0 |
| 90% | 2 | 7 |
| 80% | 12 | 40 |
| 70% | 11 | 37 |
| 60% and below | 5 | 17 |
Abbreviations: ATRX, alpha-thalassemia/mental retardation syndrome X-linked expression; EGFR, epidermal growth factor receptor; IDH, Isocitrat dehydrogenase; n.a., not available; ReRT, reirradiation; RT, radiotherapy.