Table 2.
The Value of Serum AFP, GPC3, GP73 and DCP in the Diagnosis of HCC (Including All HCC Patients)
| Biomarkers | AUC(95% CI) | P value | Sen(%) | Spe (%) | PPV(%) | NPV(%) |
|---|---|---|---|---|---|---|
| vs LC,CHB,HC | ||||||
| AFP | 0.798(0.754–0.838) | <0.0001 | 77.3 | 71.1 | 74.6 | 74.0 |
| GPC3 | 0.731(0.684–0.775) | <0.0001 | 58.6 | 84.4 | 80.6 | 65.0 |
| GP73 | 0.616(0.565–0.665) | <0.0001 | 23.7 | 99.4 | 97.9 | 54.2 |
| DCP | 0.634(0.583–0.683) | <0.0001 | 29.8 | 97.2 | 92.2 | 55.7 |
| AFP+GPC3 | 0.863(0.824–0.896) | <0.0001 | 86.9 | 71.7 | 77.1 | 83.2 |
| AFP+GP73 | 0.831(0.790–0.868) | <0.0001 | 60.1 | 95.6 | 93.7 | 68.5 |
| AFP+DCP | 0.810(0.767–0.848) | <0.0001 | 80.8 | 70.6 | 75.1 | 77.0 |
| GPC3+GP73 | 0.758(0.712–0.801) | <0.0001 | 62.6 | 84.4 | 81.6 | 67.3 |
| GPC3+DCP | 0.753(0.706–0.796) | <0.0001 | 64.1 | 83.3 | 80.9 | 67.9 |
| GP73+DCP | 0.684(0.635–0.731) | <0.0001 | 39.4 | 97.2 | 94.0 | 59.3 |
| AFP+GPC3+GP73 | 0.871(0.833–0.903) | <0.0001 | 70.2 | 89.4 | 88.0 | 73.2 |
| AFP+GPC3+DCP | 0.863(0.824–0.896) | <0.0001 | 86.9 | 71.7 | 77.1 | 83.2 |
| GPC3+GP73+DCP | 0.771(0.725–0.812) | <0.0001 | 66.2 | 83.3 | 81.4 | 69.1 |
| AFP+GPC3+GP73+DCP | 0.867(0.829–0.900) | <0.0001 | 69.7 | 89.4 | 87.9 | 72.9 |
| vs LC,CHB | ||||||
| AFP | 0.765(0.715–0.810) | <0.0001 | 61.6 | 73.1 | 77.7 | 55.6 |
| GPC3 | 0.706(0.653–0.754) | <0.0001 | 58.6 | 78.5 | 80.6 | 55.4 |
| GP73 | 0.614(0.559–0.667) | <0.0001 | 23.7 | 99.2 | 97.9 | 46.1 |
| DCP | 0.628(0.574–0.681) | <0.0001 | 29.8 | 96.2 | 92.2 | 47.3 |
| AFP+GPC3 | 0.830(0.785–0.869) | <0.0001 | 63.6 | 87.7 | 88.7 | 61.3 |
| AFP+GP73 | 0.802(0.755–0.844) | <0.0001 | 60.1 | 93.8 | 93.7 | 60.7 |
| AFP+DCP | 0.774(0.725–0.818) | <0.0001 | 51.5 | 93.8 | 92.7 | 56.0 |
| GPC3+GP73 | 0.735(0.684–0.782) | <0.0001 | 62.6 | 78.5 | 81.6 | 58.0 |
| GPC3+DCP | 0.725(0.673–0.773) | <0.0001 | 64.1 | 76.9 | 80.9 | 58.5 |
| GP73+DCP | 0.679(0.626–0.729) | <0.0001 | 39.4 | 96.2 | 94.0 | 51.0 |
| AFP+GPC3+GP73 | 0.841(0.796–0.879) | <0.0001 | 70.2 | 85.4 | 88.0 | 65.3 |
| AFP+GPC3+DCP | 0.830(0.785–0.869) | <0.0001 | 63.6 | 87.7 | 88.7 | 61.3 |
| GPC3+GP73+DCP | 0.746(0.695–0.792) | <0.0001 | 66.2 | 76.9 | 81.4 | 59.9 |
| AFP+GPC3+GP73+DCP | 0.837(0.793–0.876) | <0.0001 | 64.1 | 91.5 | 92.0 | 62.6 |
| vs LC | ||||||
| AFP | 0.775(0.721–0.824) | <0.0001 | 77.3 | 66.7 | 86.0 | 52.6 |
| GPC3 | 0.696(0.638–0.750) | <0.0001 | 58.6 | 77.3 | 87.2 | 41.4 |
| GP73 | 0.611(0.551–0.670) | <0.0001 | 23.7 | 98.7 | 97.9 | 32.9 |
| DCP | 0.624(0.564–0.682) | <0.0001 | 29.8 | 96.0 | 95.2 | 34.1 |
| AFP+GPC3 | 0.824(0.774–0.868) | <0.0001 | 68.2 | 81.3 | 90.1 | 48.8 |
| AFP+GP73 | 0.810(0.758–0.855) | <0.0001 | 60.1 | 92.0 | 95.2 | 46.6 |
| AFP+DCP | 0.784(0.730–0.831) | <0.0001 | 80.8 | 65.3 | 86.0 | 56.3 |
| GPC3+GP73 | 0.727(0.670–0.779) | <0.0001 | 62.6 | 77.3 | 87.9 | 43.9 |
| GPC3+DCP | 0.709(0.651–0.762) | <0.0001 | 64.1 | 74.7 | 87.0 | 44.1 |
| GP73+DCP | 0.675(0.616–0.730) | <0.0001 | 39.4 | 96.0 | 96.3 | 37.5 |
| AFP+GPC3+GP73 | 0.835(0.785–0.877) | <0.0001 | 70.2 | 82.7 | 91.4 | 51.2 |
| AFP+GPC3+DCP | 0.825(0.774–0.868) | <0.0001 | 66.7 | 82.7 | 91.0 | 48.4 |
| GPC3+GP73+DCP | 0.731(0.674–0.783) | <0.0001 | 66.2 | 74.7 | 87.3 | 45.5 |
| AFP+GPC3+GP73+DCP | 0.833(0.783–0.875) | <0.0001 | 64.1 | 89.3 | 94.1 | 48.6 |
Abbreviations: AFP, α-fetoprotein; GPC3, glypican 3; GP73, golgi protein 73; DCP, des-γ-carboxy prothrombin; AUC, area under curve; Sen, sensitivity; Sep, specificity; PPV, positive predictive value; NPV, negative predictive value; HCC, hepatocellular carcinoma; LC, liver cirrhosis; CHB, chronic hepatitis B virus infection; HC, healthy controls.