Table 4.
The Value of Serum AFP, GPC3, GP73 and DCP in the Very Early Diagnosis of HCC
| Biomarkers | AUC (95% CI) | P value | Sen (%) | Spe (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|
| vs LC, CHB, HC | ||||||
| AFP | 0.726(0.662–0.784) | <0.0001 | 65.0 | 76.7 | 38.2 | 90.8 |
| GPC3 | 0.601(0.533–0.666) | 0.017 | 35.0 | 85.0 | 34.1 | 85.5 |
| AFP+GPC3 | 0.751(0.688–0.807) | <0.0001 | 75.0 | 71.7 | 37.0 | 92.8 |
| AFP+GP73 | 0.725(0.661–0.783) | <0.0001 | 65.0 | 76.7 | 38.2 | 90.8 |
| AFP+DCP | 0.742(0.679–0.798) | <0.0001 | 65.0 | 76.1 | 37.7 | 90.7 |
| GPC3+GP73 | 0.601(0.533–0.666) | 0.0177 | 35.0 | 85.0 | 34.1 | 85.5 |
| AFP+GPC3+GP73 | 0.750(0.688–0.806) | <0.0001 | 75.0 | 71.7 | 33.3 | 89.7 |
| AFP+GPC3+DCP | 0.752(0.689–0.807) | <0.0001 | 75.0 | 71.7 | 37.0 | 92.8 |
| AFP+GPC3+GP73+DCP | 0.750(0.687–0.806) | <0.0001 | 75.0 | 71.7 | 37.0 | 92.8 |
| vs LC, CHB | ||||||
| AFP | 0.688(0.613–0.757) | 0.0002 | 42.5 | 93.8 | 68.0 | 84.1 |
| AFP+GPC3 | 0.703(0.629–0.771) | <0.0001 | 42.5 | 96.2 | 76.2 | 83.9 |
| AFP+GP73 | 0.687(0.611–0.756) | <0.0001 | 42.5 | 93.8 | 68.0 | 84.1 |
| AFP+DCP | 0.700(0.626–0.768) | 0.0001 | 42.5 | 93.8 | 68.0 | 84.1 |
| AFP+GPC3+GP73 | 0.702(0.627–0.770) | <0.0001 | 42.5 | 93.8 | 68.0 | 84.1 |
| AFP+GPC3+DCP | 0.704(0.629–0.771) | <0.0001 | 42.5 | 96.2 | 77.3 | 84.5 |
| AFP+GPC3+GP73+DCP | 0.702(0.627–0.770) | <0.0001 | 42.5 | 94.6 | 70.8 | 84.2 |
| vs LC | ||||||
| AFP | 0.704(0.612–0.785) | <0.0001 | 65.0 | 70.7 | 54.2 | 79.1 |
| AFP+GPC3 | 0.704(0.611–0.785) | <0.0001 | 75.0 | 61.3 | 50.8 | 82.1 |
| AFP+GP73 | 0.701(0.609–0.783) | <0.0001 | 65.0 | 70.7 | 54.2 | 79.1 |
| AFP+DCP | 0.692(0.599–0.774) | <0.001 | 42.5 | 94.7 | 81.0 | 75.5 |
| AFP+GPC3+GP73 | 0.702(0.610–0.784) | <0.0001 | 75.0 | 61.3 | 50.8 | 82.1 |
| AFP+GPC3+DCP | 0.708(0.616–0.789) | <0.0001 | 75.0 | 62.7 | 51.7 | 82.5 |
| AFP+GPC3+GP73+DCP | 0.703(0.611–0.785) | <0.0001 | 42.5 | 94.7 | 81.0 | 75.5 |
Note: AUC value of biomarkers < 0.6 is not presented.
Abbreviations: AFP, α-fetoprotein; GPC3, glypican 3; GP73, golgi protein 73; DCP, des-γ-carboxy prothrombin; AUC, area under curve; Sen, sensitivity; Sep, specificity; PPV, positive predictive value; NPV, negative predictive value; HCC, hepatocellular carcinoma; LC, liver cirrhosis; CHB, chronic hepatitis B virus infection; HC, healthy controls.