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. 2020 Jan 28;12:611–619. doi: 10.2147/CMAR.S238132

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© 2020 Hu et al.

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Expression levels of RSK4 in gastric cancer tissues and cell lines and the association of RSK4 expression with prognosis. (A) The mRNA level of RSK4 is lower in gastric cancer tissues than that in adjacent normal tissues. The data from 25 patients was obtained from the TCGA database. TCGA: The Cancer Genome Atlas. Mann–Whitney test: ****p < 0.0001. (B) The low mRNA level of RSK4 predicts a poor prognosis. Kaplan-Meier survival analysis was performed to analyze the correlation of RSK4 expression with OS in gastric cancer patients from the GEO database. OS, overall survival. GEO, Gene Expression Omnibus. (C, D) The mRNA expression and protein levels of RSK4 were analyzed using qRT-PCR and Western blot assay, respectively. Unpaired two-tailed t-test: **p < 0.01 and ***p < 0.001. (E, F) The RSK4 mRNA and protein expressions in HGC27 were measured after transfection with RSK4-si-NC, RSK4-si-1, RSK4-si-2 or RSK4-si-3. The data are represented as the mean ± s.d. Unpaired two-tailed t-test: ***p < 0.001.