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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: ACS Chem Biol. 2019 Jun 19;14(8):1677–1686. doi: 10.1021/acschembio.9b00339

Figure 1.

Figure 1.

Secondary interactions involving the main chain. (A) Structural model of an idealized β-sheet, showing conventional main-chain hydrogen bonds (black dashes), C–H···O hydrogen bonds (green dashes), and C5 hydrogen bonds (blue dashes). (B) Structural model of an idealized α-helix, showing main-chain hydrogen bonds (black dashes) and nπ* interactions (blue arrows). (C,D) Orbital overlap that underlies formation of nπ* interactions (C) and C5 hydrogen bonds (D).