Table 2.

The detailed results of all the markers in our cohort. (grouped by the WHO grade)

Variables		Grade II		Grade III		Grade IV		Total	P Value
Median age (year)		36		41		49
Age	≥ 45 years	135	76.70%	100	62.89%	88	42.11%	323	<0.001*
	< 45 years	41	23.30%	59	37.11%	121	57.89%	221
	Missing	0		0		0
Gender	Male	102	57.95%	91	57.23%	119	56.94%	312	0.983
	Female	74	42.05%	68	42.77%	90	43.06%	232
	Missing	0		0		0
IDH1	Positive	116	67.84%	73	47.40%	36	17.82%	225	<0.001*
	Negative	55	32.16%	81	52.60%	166	82.18%	302
	Missing	5		5		7		17
ATRX	Positive	73	42.94%	99	65.13%	120	60.30%	292	<0.001*
	Negative	97	57.06%	53	34.87%	79	39.70%	229
	Missing	6		7		10		23
P53	Positive	82	48.24%	91	58.33%	144	69.90%	317	<0.001*
	Negative	88	51.76%	65	41.67%	62	30.10%	215
	Missing	6		3		3		12
PHH3	High (≥ 5)	9	5.17%	136	86.62%	171	83.41%	316	<0.001*
	low(< 5)	165	94.83%	21	13.38%	34	16.59%	220
	Missing	2		2		4		8
Ki67	High (≥ 10%)	46	26.29%	118	74.21%	205	98.09%	369	<0.001*
	Low (< 10%)	129	73.71%	41	24.26%	4	1.91%	174
	Missing	1		0		0		1
1p/19q	Co-deleted	42	26.42%	43	31.16%	6	3.37%	91	<0.001*
	1p deleted	4	2.52%	7	5.07%	12	6.74%	23
	19q deleted	6	3.77%	8	5.80%	15	8.43%	29
	Intact	107	67.30%	80	57.97%	145	81.46%	332
	Missing	17		21		31		69
TERTp	Mutated	39	24.38%	55	38.73%	84	44.92%	178	<0.001*
	Wildtype	121	75.63%	87	61.27%	103	55.08%	311
	Missing	16		17		22		55
MGMTp	Methylated	35	37.23%	31	39.24%	62	51.24%	128	0.058
	Wildtype	59	62.77%	48	60.76%	59	48.76%	166
	Missing	82		80		88		250