Table 2.

Animal-origin pancreatic cancer cell lines

Cell line	Organism	Carcinogen	Differentiation degree	Gene mutation	Ref
PC1	mouse	BOP	Good	K-ras, P53	97, 98
WDPaCa	mouse	BOP	Good	P53	99
PDPaCa	mouse	BOP	Poor	k-ras	99
HPC	mouse	BOP	Poor		100
HP1	mouse	BOP			101
HaP-T1	mouse	BOP	Good-Moderate		102
H2T	mouse	BHP		K-ras, P53	103, 104
HPD(1-3)NR	mouse	BHP	Moderate	K-ras, P53	102, 105
Pan02	mouse	MCA		K-ras,smad4	106
6606PDA	mouse		Good		107-109
AR42J	rat				110, 111

Note: BHP: N-nitrosobis(2-hydroxypropyl)amine; animal-origin pancreatic cancer cell lines are commonly used in inbred mice of the same origin for allogeneic transplantation. This model is used more frequently in tumor immunology studies and to evaluate single-agent or combination immunotherapy studies.