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. 2020 Jan 1;11(6):1383–1392. doi: 10.7150/jca.32552

Figure 5.

Figure 5

TCL6 sensitizes RCC cells to PTX through sponging miR-221. A. The level of miR-221 was negatively correlated with TCL6 expression in renal cancer, which was conducted via TANRIC platform. B. The basal expression of miR-221 in HK-2, 786-O, and Caki-1 cells were evaluated by qRT-PCR. C. The expression levels of miR-221 were detected by qRT-PCR after knockdown of TCL6 in 786-O cells. D. The expression level of miR-221 was further examined with or without upregulation of TCL6 using qRT-PCR. E. TCL6 contains two potential binding sites of miR-221. F. Relative luciferase activity in wild type of TCL6. The decrease in luciferase activity in the wild type indicated specific binding of miR-221 to its target site. Data are shown as means ± SD. *P<0.05.