Table 2.
Blood flow, hematologic, and metabolic responses to maximal single leg knee-extensor exercise in patients with COPD and matched healthy controls
| COPD | Control | ||
|---|---|---|---|
| Work (Watts) | 12 ± 2 | 24 ± 4† | |
| Q̇M (l/min) | 2.45 ± 0.23 | 3.32 ± 0.32† | |
| Q̇MO2 (l/min) | 0.44 ± 0.06 | 0.69 ± 0.07† | |
| V̇MO2 (l/min) | 0.27 ± 0.04 | 0.42 ± 0.05† | |
| pHa | 7.34 ± 0.02 | 7.38 ± 0.01† | |
| pHv | 7.20 ± 0.02 | 7.23 ± 0.01 | |
| [Hb]total (g/dl) | 13.2 ± 0.4 | 15.1 ± 0.6† | |
| CaO2 (ml/dl) | 17.7 ± 0.8 | 21.0 ± 0.8† | |
| CvO2 (ml/dl) | 6.8 ± 0.9 | 8.3 ± 0.6† | |
| PaO2 (mmHg) | 88 ± 13 | 116 ± 3† | |
| PvO2 (mmHg) | 25 ± 1 | 28 ± 2† | |
| PaCO2 (mmHg) | 43 ± 4 | 31 ± 4† | |
| PvCO2 (mmHg) | 67 ± 5 | 61 ± 3† | |
| SaO2 (%) | 95 ± 1 | 98 ± 0† | |
| SvO2 (%) | 36 ± 4 | 39 ± 3 | |
| MAP-MVP (mmHg) | 109 ± 4 | 121 ± 7† | |
| Heart rate (bpm) | 104 ± 6 | 112 ± 4 | |
| DMO2 (ml/min/mmHg) | 6.6 ± 0.8 | 10.4 ± 0.9† | |
| PcapO2 (mmHg) | 36 ± 1 | 46 ± 2 | |
| Net venous lactate outflow (mmol/min) | 3.1 ± 0.5 | 4.6 ± 1.1 |
Values are mean ± SE. Q̇M, Quadriceps muscle blood flow; Q̇MO2, quadriceps muscle O2 delivery; V̇MO2, quadriceps muscle O2 consumption; pHa, arterial pH; pHv, venous pH; [Hb]total, total hemoglobin; CaO2, arterial O2 content of blood; CvO2, venous O2 content of blood; PaO2, partial pressure of arterial O2; PvO2, partial pressure of venous O2; PaCO2, partial pressure of arterial CO2; PvCO2, partial pressure of venous CO2; SaO2, arterial O2 saturation; SvO2, venous O2 saturation; MAP, mean arterial pressure; MVP, mean venous pressure; DMO2, O2 diffusional conductance; PcapO2, mean capillary partial pressure of O2;
significantly different from Controls (p < 0.05).