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. Author manuscript; available in PMC: 2020 Jun 19.
Published in final edited form as: Sci Transl Med. 2019 Jun 19;11(497):eaaw0790. doi: 10.1126/scitranslmed.aaw0790

Fig. 4. Organ culture with JQ1 mitigates pro-fibrotic gene expression in SSc skin.

Fig. 4.

mRNA in situ hybridization for TGFB2 (green foci) and COL1A1 (red foci) in the dermis of healthy control skin and SSc lesional skin biopsies maintained in organ-culture with DMSO or JQ1 for 10 days. Scale bars, 20 um. Total number of fluorescent foci normalized to the number of nuclei was quantified and averaged from three different sections per biological replicate. ***P < 0.001. ncontrol = 4, nssc = 4. One-factor ANOVA with FDR correction was used for all experiments. Black points represent individual biological replicates.