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. 2020 Jan 19;2020:8140989. doi: 10.1155/2020/8140989

Figure 4.

Figure 4

AFAP1-AS1 positively regulated FGF7 by sponging miR-155-5p. (a) The putative interacting sequence between FGF7 and miR-155-5p was obtained from TargetScan. (b, c) Dual-luciferase reporter assay further validated the combination between miR-155-5p and FGF7 in BGC-823 and SGC-7901 cells. (d) FGF7 was overexpressed in GC tissues (t = 12.59, P < 0.0001). (e) The expression correlation between AFAP1-AS1 and FGF7 in GC tissues was analyzed. (f) The expression correlation between miR-155-5p and FGF7 was assessed. (g, h) The increased expression of miR-155-5p in BGC-823 and SGC-7901 cells was separately measured after transfection of si-AFAP1-AS1-2. (i, j) The decreased expression of FGF7 in BGC-823 and SGC-7901 cells was separately measured after transfection of si-AFAP1-AS1-2. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001.