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Construction of dual targeting and co-delivery system: Doxorubicin (DOX) was embedded into the TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) plasmid to generate a steady composite, which was further condensed by choline-derivate modified DGL. This co-delivery system could accumulate into glioma cells through EPR and dual targeting effect. After cytoplasm releasing, TRAIL and DOX exert combination therapy on glioma. Reproduced with permission from Reference [134].
