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. 2019 Dec 12;9(12):867. doi: 10.3390/biom9120867

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Serum (A) and retinal (B–D) sterols. WT1, wild type mice (C57BL/6J) for the Soat1^−/−, Apoe^−/−, Cyp27a1^−/−Cyp46a1^−/−Soat1^−/−, and Cyp27a1^−/−Cyp46a1^−/−Apoe^−/− genotypes; WT2, wild type mice (C57BL/6J; 129S6/SvEv) for the Cyp27a1^−/−Cyp46a1^−/− genotype. The results are presented as means ± SD of the individual measurements in 3–7 animals/genotype/sex; number of mice equals the number of retinas; animals were 6–8-months old. Statistical significance was assessed by two-way ANOVA with Bonferroni correction. Black lines and asterisks indicate statistically significant differences between sexes of the same genotype; the results of the other comparisons are summarized in Tables S2–S5. ** p ≤ 0.01; *** p ≤ 0.001.