Figure 6.

The impact of high glucose and tryptophanol or halofuginone on TGF-β1 and IL-8 production. Mesothelial cells were cultured under normal or high-glucose conditions in the presence or not of halofuginone or tryptophanol. TGF-β1 and IL-8 production was assessed by their concentrations in cell culture supernatants. High glucose enhanced TGF-β1 level, tryptophanol reduced the degree of high-glucose-induced TGF-β1 increment, and halofuginone exerted the same effect, to a greater extent (A). High glucose increased IL-8 concentration; tryptophanol reduced the degree of high-glucose-induced IL-8 rise, followed by halofuginone to a lesser degree (B). *, #, +, ^, $, and & indicate a p < 0.05 compared to first, second, third, fourth, fifth, or sixth depicted conditions. Error bars correspond to standard error of means.