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. 2019 Nov 28;9(12):800. doi: 10.3390/biom9120800

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Correlation study of cerebrospinal fluid (CSF) mitochondrial malate dehydrogenase 1 (MDH1) levels with tau and 14-3-3 amounts. CSF-levels of MDH1, tau, and 14-3-3 from the same patients were correlated to detect potential association among neurodegenerative markers. (A–F). In gCJD (E200K and V210I) patients, a positive correlation was obtained between MDH1 and tau levels (E200K: r = 0.39; p < 0.01 **; n = 45), (V210I: r = 0.51; p < 0.01 **; n = 46). No correlation was detected between MDH1 and tau in FFI cases. MDH1 and 14-3-3 did not correlate at all.