Figure 3.

Cell adhesion mediated drug resistance (CAM-DR) in W1 and W1CR cells induced by COL1 binding: (a) Increase of EC₅₀ values of cisplatin cytotoxicity in W1 and W1CR cells when cultivated on COL1 surfaces. Data are means of at least n = 3 (±SEM), asterisks indicate statistical significance: ** p < 0.01; *** p < 0.001; ****p < 0.0001. (b,c) Scatter plots of upregulated and downregulated genes (fold change >3 / <−3) upon cell cultivation on a COL1 matrix in (b) W1 cells and (c) W1CR cells, (d) Chord plot representing association between genes deregulated in W1CR cells upon cultivation on COL1 and gene ontology (GO) term analysis.