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. 2019 Dec 1;9(12):810. doi: 10.3390/biom9120810

Figure 3.

Figure 3

Effects of LSD1 knock-out on HCC cell cycle in vitro. LSD1 knock-out SNU-423 cells (A) and SNU-475 cells (B) generated by the CRISPR/Cas9 system with two guide RNAs were obtained by treatment with Dox. Flow cytometry was conducted to investigate the effects of LSD1 knockout on HCC cell cycle. LSD1 knockout decreased the number of cells at S phase in each cell lines. While it increased the number of cells at G2/M phase in SNU-423 cells, it increased the number of cells at G0/G1 phase in SNU-475 cells. All data are represented as mean ± s.d. * p < 0.01; ** p < 0.001.