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. 2019 Dec 6;9(12):840. doi: 10.3390/biom9120840

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Results of an in vivo rabbit calvarial defect model treated with cellulose-based composites, using HA-particles with either 20 µm (µHA) or 100 nm (nHA) in diameter, compared to untreated control. Figures above: 2D images and 3D reconstructions by means of µ-CT of the control and implanted composites after 4- and 12-week treatment, respectively. Margin of the initially created defect is highlighted by red arrows. Scale bar corresponds to 3 mm. Graph below: Ratio of bone volume (BV) to total volume of the created defect (TV). * indicate a significant deviation from control; ** indicate a significant deviation from cellulose/μHA. Reproduced from work in [127] with permission from John Wiley and Sons, 2019.