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. 2019 Nov 26;9(12):782. doi: 10.3390/biom9120782

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Results of HER2 IHC, HER2 silver in situ hybridization (SISH), and trastuzumab IHC in two cases among consecutive gastric cancer patients. Case 1 shows negativity by HER2 IHC, however, HER2 amplification was confirmed by SISH, and was 3+ by trastuzumab IHC. Case 2 showed 3+ by both HER2 and trastuzumab IHC, and HER2 gene amplification was observed as well.