Table 4.
Clinicopathologic characteristics of consecutive gastric cancer patients according to HER2 status.
| HER2 Negative | HER2 Positive | p-Value | |
|---|---|---|---|
| Age | |||
| <65 | 306 (61.0%) | 13 (50.0%) | 0.265 |
| ≥65 | 196 (39.0%) | 13 (50.0%) | |
| Sex | |||
| Male | 334 (66.5%) | 18 (69.2%) | 0.776 |
| Female | 168 (33.5%) | 8 (30.8%) | |
| Location | |||
| Lower | 256 (51.0%) | 15 (57.7%) | 0.444 |
| Middle | 153 (30.5%) | 7 (26.9%) | |
| Upper | 78 (15.5%) | 4 (15.4%) | |
| Entire | 15 (3.0%) | 0 (0.0%) | |
| Histology | |||
| WD | 57 (11.4%) | 11 (42.3%) | <0.001 |
| MD | 163 (32.5%) | 14 (53.8%) | |
| PD | 193 (38.4%) | 1 (3.8%) | |
| SRC | 74 (14.7%) | 0 (0.0%) | |
| Mucinous | 15 (3.0%) | 0 (0.0%) | |
| Lauren classification | |||
| Intestinal | 211 (42.0%) | 25 (96.2%) | <0.001 |
| Diffuse | 241 (48.0%) | 1 (3.8%) | |
| Mixed | 50 (10.0%) | 0 (0.0%) | |
| Lymphatic invasion | |||
| Absent | 260 (51.8%) | 15 (57.7%) | 0.557 |
| Present | 242 (48.2%) | 11 (42.3%) | |
| Vascular invasion | |||
| Absent | 445 (88.8%) | 24 (92.3%) | 0.756 |
| Present | 56 (11.2%) | 2 (7.7%) | |
| Perineural invasion | |||
| Absent | 329 (65.5%) | 23 (88.5%) | 0.017 |
| Present | 173 (34.5%) | 3 (11.5%) | |
| pTNM stage | |||
| I | 261 (52.0%) | 17 (65.4%) | 0.167 |
| II | 79 (15.7%) | 4 (15.4%) | |
| III | 139 (27.7%) | 4 (15.4%) | |
| IV | 23 (4.6%) | 1 (3.8%) | |
| Total | 502 (95.1%) | 26 (4.9%) | |
Abbreviations: WD, well differentiated; MD, moderately differentiated; PD, poorly differentiated; SRC, signet ring cell carcinoma; pTNM.