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. 2019 Dec 1;9(12):811. doi: 10.3390/biom9120811

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Behavioral and electrophysiology results in pigs. (A) PTIBS locomotor scores of pigs of the FM (blue line) and FM + AD-MSCs + LV-EGFP (red line) groups. Significant differences between the experimental groups throughout the experiment were not found. Electrophysiology results demonstrate SEPs (B) before SCI (reproducible peaks from lumbar and scalp electrodes) and (C) after 15 min after SCI (reproducible peaks of lesser amplitude from lumbar electrodes only). (D,E) At 22 weeks, in the control group with FM application, only one pig had a peak from lumbar enlargement on one side. (F) While in the experimental group with FM + AD-MSCs application, cortical peaks on one side and peaks from lumbar enlargement on both sides were recorded in one pig. MEPs from the tibialis anterior muscle in pigs (G) before SCI and after 22 weeks in groups with (H) FM and (I) AD-MSCs application with registration of MEPs on one side.