Study	Reason for exclusion
Arimura 2009	Retrospective, comparative study
Fulda 2010	Not a randomised clinical trial. Each participant received the 2 evaluated interventions. The right eye received intravitreal bevacizumab and 1 session of 800 scattered laser spots. The left eye underwent a full 1600 laser panretinal photocoagulation
Genovesi‐Ebert 2007	Not a randomised clinical trial
Gonzalez 2006	RCT assessed the efficacy and safety of pegaptanib in treating diabetic macular oedema and diabetic retinopathy. The publication was an abstract and there was insufficient information to include the study. The principal focus is of participants with macular oedema
Hattori 2010	Not a randomised clinical trial
Huang 2009	Compared with historical controls. Not randomised
Ip 2012	2 years of follow‐up to evaluate effects of intravitreal ranibizumab on diabetic retinopathy severity over time in 2 phase 3 clinical trials (RIDE, NCT00473382; RISE, NCT00473330) for diabetic macular oedema
Jiang 2009	Retrospective study
Jorge 2006	Non‐randomised study
Lanzagorta‐Aresti 2009	The included participants did not have proliferative diabetic retinopathy. The outcomes measured were central macular thickness and visual acuity in participants with a moderate retinopathy not proliferative that needed a cataract surgery
López‐López 2012	Anti‐VEGF group was not randomised
Michaelides 2010	Focus of the clinical trial was diabetic macular oedema
Minnella 2008	Non‐controlled clinical trial
Scott 2008	Study evaluated agreement in diabetic retinopathy severity classification by retina specialists performing ophthalmoscopy vs. reading centre grading of 7‐field stereoscopic fundus photographs in a phase 2 clinical trial of intravitreal bevacizumab for centre‐involved diabetic macular oedema
Shin 2009	Data were collected retrospectively
Stergiou 2007	Retrospective case series
Tonello 2008	Quote: "for patients (n= 8) presenting with high‐risk PDR [proliferative diabetic retinopathy] in both eyes, the eye with worse BCVA [best‐corrected visual acuity] was selected to receive PRP [panretinal photocoagulation] plus intravitreal bevacizumab (eight eyes) and the fellow eye was treated with PRP alone (eight eyes)" Comment: clinical trial partially randomised
Yeh 2009	Not a randomised study. The treatment assignment was alternative
Zhou 2010	Focus of the clinical trial is diabetic macular oedema