Figure 2.

Mechanism of heart failure onset in diabetes. The risk of heart failure in T2DM patients is high because of organic and functional abnormalities in the heart. The chronic hemodynamic load on the damaged heart induces heart failure. In the short term, SGLT2 inhibitors reduce the hemodynamic load imposed on the heart by suppressing excessive activation of the sympathetic nervous system, thereby suppressing the onset of heart failure. T2DM: type 2 diabetes mellitus, SGLT2: sodium glucose cotransporter 2