Figure 1.
Course of experimental autoimmune encephalomyelitis (EAE). Mice were immunized with peptides 35-55 of myelin oligodendrocyte glycoprotein (MOG35-55) in complete Freund’s adjuvant and simultaneously administered Goreisan. Data are shown as the mean EAE scores of all immunized mice ±the standard error of the mean (SEM) (A). The mean EAE scores of Goreisan-treated mice were significantly lower than those of non-treated mice (■: Goreisan-treated, and ●: sham-treated mice, both n=14). Disease features are summarized in Table. Goreisan was administered from day 10, after the onset of paralytic symptoms (B). EAE score was not significantly different between the Goreisan- and non-treated mice (■: Goreisan-treated and ●: sham-treated mice, both n=8).