KEY RESOURCES TABLE

Reagent or resource	Source	Identifier
Antibodies
Ckytokeratin (pan)	Sigma	C2562
Ckytokeratin (pan)	Novus Biologicals	NB120-11213
Six2	Proteintech	11562-1-AP
Troma-1	DSHB	troma-1
Pax2	R&D Systems	AF3364
Sox9	Abcam	Ab185230
MYC	Abcam	Ab32072
RFP	Thermo Fisher Scientific	MA5-15257
GFP	Aves Lab	GFP-1020
Bacterial and Virus Strains
Biological Samples
Chemicals, Peptides, and Recombinant Proteins
Doxycycline	Sigma	D9891
Critical Commercial Assays
Deposited Data
Experimental Models: Cell Lines
Experimental Models: Organisms/Strains
Mouse: B6;D-Tg(Wnt11-TagRFP/cre/ERT2)28Amc/J	McMahon Lab, The Jackson Laboratory	018683
Mouse: Adamts18−/−	Knock-Out Mouse Project	VG 12442
Mouse: Tg(tetO-HIST1H2BJ/GFP)47Efu/J	The Jackson Laboratory	005104
Mouse: B6N.Cg-Tg(tetO-GFP,-lacZ)G3Rsp/J	The Jackson Laboratory	018913
Mouse: B6.Cg-Tg(tetO-DTA)1Gfi/J	The Jackson Laboratory	008468
Mouse: FVB/N-Tg(tetO-MYC)36aBop/J	The Jackson Laboratory	019376
Mouse: B6.Cg-Gt(ROSA)26Sortm1(tetO-YAP1*,GFP*)Stang/J	Stanger Lab, The Jackson Laboratory	031279
Oligonucleotides
Adamts18 in situ probe primers: Forward: acccttgtcctgagaatagcttg Reverse: TAATACGACTCACTATAGGGgaggaattgacttgggtgtgttg	Rutledge et al., 2017	N/A
rtTA in situ probe primers: Forward: GCGCTCTGGAATTACTCAATGGA Reverse: TAATACGACTCACTATAGGGTAGAATCGGTGGTAGGTGTCTCT	This paper	N/A
Recombinant DNA
Software and Algorithms
Amira	Thermo Scientific	N/A
Imaris v9.2.0	Oxford Instruments/Bitplane	N/A
ImageJ	National Institutes of Health	N/A
Other