Table 2:

summary of findings with respect to requirements for mammary gland development in mice. WT, wildtype; OVX, ovariectomized (not from this study); LD, lipodystrophic; E2, estradiol; Adipose refers to rescue with preadipocytes resulting in an ectopic adipose depot. ND, not determined.

Condition	Leptin	Estradiol	Mammary adipose	Mammary gland development	Pregnancy
WT	+	+	+	+	+
OVX	(+)	(−)	(+)	(−)	(−)
LD	−	−	−	−	−
LD+Adipose	+	+	−	−	+
LD+E2	−	+	−	−	ND
Ob	−	−	+	−	−
Ob+Adipose	+	+	+	+	+
Ob+E2	−	+	+	−	ND