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. Author manuscript; available in PMC: 2021 Jan 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2019 Dec 3;387:114849. doi: 10.1016/j.taap.2019.114849

Figure 2:

Figure 2:

PDK4 deficiency protected mice against APAP hepatotoxicity. (A) Female wild type and PDK4−/− mice were treated with 600 mg/kg APAP and plasma ALT activities were measured at 0h, 2h, 6h and 24h post APAP. (B) Male wild type and PDK4−/− mice were treated with 300 mg/kg APAP and plasma ALT activities were measured. Data represent means ± SE of n = 4–6 animals per time point. *p < 0.05 (compared to controls, t = 0). #p < 0.05 (compared to the respective APAP group).