Table 3. Association between duration of GnRHa use and cerebrovascular attack, IHD, MI, and DM^a .

Variables		CVA		IHD
		HR	95% CI	HR	95% CI
Duration of GnRHa use, mon
	No use	Reference		Reference
	≤ 12	1.302	0.910–1.895	0.654	0.517–1.685
	13–24	0.982	0.598–1.180	1.194	0.752–1.594
	25–36	1.652	1.021–2.025	1.359	0.845–1.726
	≥ 37	1.215	0.877–1.524	1.217	0.612–1.783
P value		0.090		0.139

Statistically significant values indicate bold.

GnRHa = gonadotropin-releasing hormone agonist, IHD = ischemic heart disease, MI = myocardial infarction, DM = diabetes mellitus, CVA = cerebrovascular attack, HR = hazard ratio, CI = confidence interval.

^aMultivariate Cox regression models were used to estimate primary outcomes. All models were adjusted for age at diagnosis, residence (urban vs. suburban/rural), socioeconomic status (National Health Insurance vs. Medicaid), prior medication, prior antiandrogen use, past medical history, and comorbidity index.