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. 2019 Sep 23;10(1):43–80. doi: 10.1016/j.jceh.2019.09.007
Consensus statements Level Grade
  • HCC is a rare tumor in children. However, it is the second most common primary liver cancer after hepatoblastoma.

I
  • Hepatitis B is the most common cause of HCC in older children in countries with a high prevalence of the infection; now reduced incidence as neonates being vaccinated.

I
  • Etiologies like tyrosinemia type 1, PFIC 2, Glycogen storage disorders type 1 and IV are predisposed to development of HCC in children

I
  • In India, majority of HCCs are discovered on explants with etiology of metabolic liver disease and not Hepatitis B

II-2
  • Hepatoblastomas need to be differentiated from HCCs and occur in a younger age group: usually less than 2 years of age and in the absence of background cirrhosis.

I Strong
  • The best treatment option for HCC in children is curative resection.

I Strong
  • Systemic chemotherapy with cisplatin and doxorubicin (PLADO) with or without sorafenib improves survival in children with HCC either as a neoadjuvant before resection or in unresectable tumors.

II-2 Weak
  • Role of sorafenib is not established in children.

II-3
  • TACE may have a role in advanced HCC in children.

II-3 Weak
  • There is no data on RFA for HCCs in children.

II-3
  • Selection criteria for liver transplantation are individual based and transplant could be considered in children with no extra-hepatic tumor or gross vascular invasion on imaging, irrespective of the number or size of the lesions.

II-2 Weak

TACE, transarterial chemoembolization; HCC, hepatocellular carcinoma; RFA, radiofrequency ablation; PFIC, progressive familial intrahepatic cholestasis.