Consensus statements	Level	Grade
• Tissue diagnosis of HCC is not required in majority of cases. Following are the indications of tissue diagnosis: ∘ When imaging and other findings are equivocal or not typical. ∘ May be indicated in suspected HCC <2 cm ∘ May be indicated in larger lesions in non-cirrhotic livers	II-2	Strong
•Needle track seedlings of HCC may deter liver biopsy	II-2	Strong
•All Resected specimens should be submitted for histopathologic evaluation	II-2	Strong
•FNACs may not yield sufficient material for immunohistochemistry unless cell-blocks are prepared. Hence, needle core biopsies, at least 2 are recommended.	II-2	Strong
•Histological distinction of some small HCCs from benign/dysplastic nodules may be difficult	II-3	Weak
•Immunohistochemistry would be necessary for confirming the diagnosis and prognostic sub-classification in most cases.	II-1	Strong
• Minimum requirements in reporting HCC are: ∘ Grading of HCC must be included in the reporting guidelines: Either standard 4 scale Edmonson Steiner Classification (Grade I-IV) or 4 Grade system (Well Differentiated/Moderately Differentiated/Poorly Differentiated/Undifferentiated) ∘ As far as possible Histological Variants must be indicated: e.g. trabecular, macrotrabecular, acinar, pseudoglandular, solid, clear, fibrolamellar HCC, steatohepatitic HCC, scirrhous HCC, mixed HCC-CCA. ∘ Presence of microemboli must be indicated ∘ State of adjacent/rest of liver must be highlighted including cirrhosis, chronic hepatitis, NAFLD, metabolic liver disease, etc. This is mandatory in resected specimens ∘ Infiltrated/clear margins of a resected specimen must be indicated	II-2	Strong