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Production and actions of ET-1 [7]. ET-1 begins as prepro-ET-1, is converted to big ET-1, and then ET converting enzyme cleaves it into the C-terminal fragments and biologically active ET-1. Biologically active ET-1 then goes out to exert its effects on the body, mediated by ETA and ETB receptors. ET-1, endothelin-1; ETA endothelin A; ETB, endothelin B; ETBR, ETB receptors.
