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. 2020 Jan 23;10:3132. doi: 10.3389/fimmu.2019.03132

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Copyright © 2020 Qin, Wang, Wu, Williams, Xu, Kranz, Guo, Guan, Vinters, Lee, Xie, Luo, Sun, Sun, He, Lu, Kamata, Wen and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Developing timed-release nanocapsules of RTX. (A) Scheme of the synthesis of and release by timed-release RTX nanocapsules (n-RTX) by (1) enriching zwitterionic monomer (MPC), hydrolysable crosslinker 1 (PLA-PEG-PLA) and non-hydrolysable crosslinker 2 (GDMA) around a RTX molecule, (2) in-situ polymerization of the monomer and crosslinkers forming a thin shell of polymer around an RTX molecule, and (3) releasing RTX when polymer shells are degraded under physiological condition. (B) Transmission Electron Microscopy image of n-RTX. (C) Size distribution of n-RTX measured by dynamic light scattering measurement. (D) Nanocapsules with mixed hydrolysable crosslinkers achieve timed release of RTX in rhesus macaque plasma. The nanocapsules synthesized with mixed PLA-PEG-PLA and GDMA crosslinkers at different ratios. Release kinetics of n-RTX with 100, 50, 30, 10, and 0% of PLA-PEG-PLA were tested. Thirty micrograms of nanocapsules were incubated in 1 mL of rhesus macaque plasma at 37°C. The concentration of released RTX was determined by ELISA.