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Evidence of reversion of the NS5-K61A/E218A mutant increases after Vero cell passage
| Virus | P0 | P1 | P5 |
|---|---|---|---|
| K61A | < 0.1% | < 0.1% | < 0.1% |
| E218A | < 0.1% | < 0.1% | 0.2% |
| K61A/E218A | 3.3% / 2.8% | 5.0% / 4.1% | 41% / 47% |
The frequency of reversion in single nucleotide variants (SNVs) of cell culture stocks of each NS5 mutant are listed. The limit of SNV detection for the LoFreq analysis was 0.1%.
P0, P1, P5 = Vero cell passage 0, 1, or 5
