Figure 2.

Cell-type specific TDP-43 pathology differs between individuals. Pathological TDP-43 staining, demonstrating (A) predominantly glial inclusions; (B) mixed glial and neuronal inclusions and (C) predominantly neuronal inclusions. Images are taken at 20× magnification; red arrows indicate neurons and blue arrows indicate glial cells. (D) Frequency distribution demonstrating the number of cases with each of these characteristic cell-type specific inclusions. Each column is subdivided into red (evidence of cognitive dysfunction) and blue (no evidence of cognitive dysfunction) showing that there is no apparent link between cell-type specific TDP-43 accumulation and cognitive dysfunction in the cases that we analysed. ALS, amyotrophic lateral sclerosis; TDP-43, 43 kDa Tar-DNA binding protein.