Fig. 1.

Overview of ATAC-seq datasets increase and sample output for pre-analysis and advanced analysis. a The number of ATAC-seq datasets, ATAC-seq publications, DNase-seq datasets, FAIRE-seq datasets, and MNase-seq datasets in PubMed from 1 Jan 2013 to 1 Oct 2019. b Typical fragment size distribution plot shows enrichment around 100 and 200 bp, indicating nucleosome-free and mono-nucleosome-bound fragments. c Typical TSS enrichment plot shows that nucleosome-free fragments are enriched at TSS, while mono-nucleosome fragments are depleted at TSS but enriched at flanking regions. d Typical peak annotation pie chart shows that more than half of the peaks fall into enhancer regions (distal intergenic and intronic regions), and only around 25% of the peaks are in promoter regions. TSS: transcription start site