Table 2.

Phenotypic groups of IgG4-RD (derivation cohort)^*

Variables used to identify groups†	Group 1 ‘Pancreato-Hepato-Biliary’ (%)	Group 2 ‘Retroperitoneum and Aorta’ (%)	Group 3 ‘Head and Neck-Limited’ (%)	Group 4 ‘Mikulicz and Systemic’ (%)	P value
Pancreas	87	12	15	46	<0.001
Liver	13	1	2	5	<0.001
Biliary	55	<1	<1	27	<0.001
Orbital	<1	3	22	<1	<0.001
Extraocular muscle	<1	1	13	4	<0.001
Sinusitis	3	<1	17	16	<0.001
Parotid gland	2	1	22	49	<0.001
Submandibular gland	15	5	50	77	<0.001
Lacrimal gland	3	3	60	48	<0.001
Renal	11	13	5	36	<0.001
Lung	2	15	7	39	<0.001
Lymph node	15	25	29	67	<0.001
Prostate	1	<1	<1	14	<0.001
Thoracic aorta	1	10	1	3	<0.001
Abdominal aorta	3	22	<1	13	<0.001
Retroperitoneum	4	53	2	8	<0.001
Proportion of cohort	31	24	24	22
Average probability (Mean)	93	92	90	90

^*Only cases (n=478) with complete covariate data are included in the latent class analysis with covariates.

^†All percentages are probabilities that the manifestation occurs in that group, conditional on latent class membership (eg, totals will not equal 100%).

IgG4-RD, IgG4-related disease.