Figure 1.

Characteristics of streptozotocin (STZ)‐induced diabetes in Sprague‐Dawley rats. Rats were given a single injection of STZ or vehicle and then followed over time. A, STZ‐injected rats exhibited hyperglycemia throughout the course of the experiment, and this was equivalent in Trpc6 ^wt/wt and Trpc6 ^del/del rats. Vehicle‐injected rats of both genotypes exhibited normal and stable blood glucose concentration. B, Vehicle‐injected rats continued to gain weight over the next 10 wk, but STZ‐injected rats did not gain weight. There was no discernible difference between Trpc6 ^wt/wt and Trpc6 ^del/del rats. C, Plasma C‐peptide was very low in STZ‐injected rats but not in vehicle‐injected rats. For unknown reasons, plasma C‐peptide levels increased between 4 and 8 wk of age, but this happened in both Trpc6 ^wt/wt and Trpc6 ^del/del rats. D, STZ treatment resulted in increased plasma triglycerides in Trpc6 ^wt/wt and Trpc6 ^del/del rats. E, STZ treatment also increased plasma total cholesterol in Trpc6 ^wt/wt and Trpc6 ^del/del rats. In this and all subsequent figures, data are presented as mean ± SEM