Figure 4.

Abundance of Canonical transient receptor potential‐6 (TRPC6) and podocin in renal cortex. A, Immunoblot analysis showing increase in TRPC6 content at 10 wk after streptozotocin (STZ) injection in Trpc6 ^wt/wt rats, and extremely low abundance of truncated TRPC6 in Trpc6 ^del/del rats as described previously.25 A typical immunoblot showing results from representative animals is shown to the left, whereas densitometric analysis from the groups of animals is shown to the right. Note that those remaining TRPC6 proteins are not functional.25 B, There was no consistent effect of drug treatment or genotype on podocin abundance of renal cortex. A typical immunoblot showing results from representative animals is shown to the left, whereas densitometric analysis from the groups of animals is shown to the right. C, There was no consistent effect of drug treatment or genotype on TRPC5 abundance of renal cortex. A typical immunoblot showing results from representative animals is shown to the left, whereas densitometric analysis from the groups of animals is shown to the right