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. 2019 Dec 24;4(2):193–207. doi: 10.1002/hep4.1453

Figure 2.

Figure 2

Icosabutate improves glucose metabolism and insulin sensitivity. Ob/ob mice were left untreated (control) or treated with icosabutate, fenofibrate, or pioglitazone for 5 weeks. Blood glucose (A), plasma insulin (B), blood hemoglobin A1c (C), HOMA‐IR (D), and plasma adiponectin (E) and plasma ALT (F) levels were measured after 4 weeks of treatment. Oral glucose tolerance test was performed in 4‐hour‐fasted ob/ob mice after 5 weeks of treatment. Blood glucose levels (G) were measured before (basal) and 15, 30, 45, 60, and 120 minutes after oral glucose load, and the AUC (H) was calculated. Values represent the mean ± SEM for 10 mice per group (*p < 0.05, **p < 0.01, ***p < 0.001 versus control). Abbreviations: HbA1c, hemoglobin A1c; OGTT, oral glucose tolerance test.