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. 2019 Dec 24;4(2):193–207. doi: 10.1002/hep4.1453

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© 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Icosabutate reduces the hepatic concentrations of lipotoxic lipid species and oxidative stress markers. Icosabutate reduces hepatic concentrations of lipotoxic lipid species: FFAs (A), DAGs (B), bile acids (C), arachidonic acid (D), ceramides (E), and HETEs (F) (comprising 11[R]‐, 12‐, and 15[S] isomers) in APOE*3Leiden.CETP mice fed a high‐fat/cholesterol diet and left untreated (control) or treated with icosabutate or rosiglitazone for 20 weeks. Icosabutate significantly improves the GSH/GSSG ratio (H) through a reduction in hepatic GSSG concentrations (G). No effect on any parameter was noted for rosiglitazone except a significant increase in HETEs. Data are presented as mean ± SEM for 12 mice per group (*p < 0.05, **p < 0.01, ***p < 0.001 versus control).